Modern BCAA+ 536g

USP Labs Modern BCAA+ 536g DescriptionEquipped With 10 Grams Per Serving Of Micronized AminosWe made it VERY clear to our R & D team - USPlabs Modern BCAA+ MUST be developed under these strict rules:BCAA Ratio formulation with mTOR activation in mind*Ultra-MicronizedMust Mix CleanNo Artificial ColorsNo Artificial FlavorsGREAT tasteNo L-Glutamine Little Known Anabolic Pathway - mTORIf you've never heard of mTOR (and even if you have), listen up and listen good as this is one of THE most under-rated anabolic & protein synthesis pathways known to man* And chances are you're not even coming close to maximizing its enormous potential!mTOR (Mammalian Target of Rapamycin) is a large proline-directed serine-threonine protein kinase that's responsible for a wide range of physiologic and metabolic functions in several cell types, including both adipocytes (fat cells) and myocytes (muscle cells)Among its many roles, mTOR is responsible for hypertrophic growth (an increase in muscle cell size, for example), protein synthesis and tissue morphogenesis*As a result, compounds which target the regulatory pathways of mTOR have been highly sought out for quite some timeA wide range of data have suggested that amino acids are capable of directly promoting mTOR signaling pathways in skeletal muscle (1, 2, 3, 4), including the possibility that they activate some of the cell signaling elements upstream from mTOR in the insulin/growth factor signaling pathway*Unlike Your Mom, mTOR DOES Play FavoritesHowever, this same data suggest that the amino-acid induced activation of mTOR signaling pathways is not uniform, and there is evidence that the mechanism of mTOR activation may be both tissue and amino acid specific (5, 6).*In particular, the amino acid leucine is indicated as being primarily responsible for the branched chain amino-acid induced activation of mTOR signaling pathways, and therefore mTOR's effect on protein turnover and synthesis* (1-6).This hypothesis has come about as studies have suggested that most of the effects of amino acids on mTOR signaling are abolished by lowering the concentration of leucine, or increased by adding leucine and, to a lesser extent, the other branched-chained amino acids.* Leucine IS the StarBUT In other words, leucine is the star, but it also must be mentioned that the other two BCAA's, isoleucine & valine, need to be present in order to support maximal results*8-1-1 BCAA RatioWith the above in mind, we've formulated USPlabs Modern BCAAwith an 8-1-1 leucine-isoleucine-valine ratioIn terms of the leucine, the reasoning here is that, from a strictly technical standpoint, the data suggests that only leucine and those other amino acids structurally related to leucine are responsible for the increase in mTOR commonly associated with BCAA supplementation.* Results & ValueAs you know, many people are doubling, tripling, even quadrupling their dosage of BCAAs with a 2:1:1 & 4:1:1 bias in order to achieve better resultsGiven the fact that leucine is most likely the amino acid responsible for this effect, particularly in skeletal muscle, having a formula with an 8:1:1 ratio may reduce the need for such increased dosing.Effectively creating an enormous value in addition to the other benefits. 3 Men Enter - 1 Man LeavesThe other issue here is amino acid transport and metabolism. All three of the branched chain amino acids - leucine, isoleucine and valine - compete for the same transport systems, and as a result, the presence of high concentrations of the other two branch-chained amino acids may lower intracellular levels of leucine* Obviously NOT what you want